Benralizumab Auto-Injector (BENRALIZUMAB - INJECTION)

Instructions

This medicine is injected into the skin. Ask your doctor, nurse, or pharmacist where on your body this medicine can be injected and how to inject it.

Carefully follow the instructions for preparing this medicine before injection.

Always inspect the medicine before using.

The liquid should be clear or light yellow.

Do not use the medicine if it contains any opaque particles or if it has changed color.

Check the medicine before each use. If the liquid medicine has any particles in it, appears discolored, or if the vial appears damaged, do not use it.

It is normal for the medicine to contain tiny clear or white particles or air bubbles.

Do not shake the medicine before using.

Store new medicine in the refrigerator until you are ready to use it. Do not allow them to freeze.

Keep the medicine in its original container.

If the medicine becomes frozen, you will need to throw it away.

You may store this medicine at room temperature for up to 14 days. Do not put back in refrigerator.

Do not store above 77 degrees F (25 degrees C).

If your medicine is stored in the refrigerator, take it out of the refrigerator about 30 minutes before use to warm to room temperature.

Injecting cold drug may be uncomfortable.

Discard unused medicine after 14 days at room temperature.

Never use any medicine that has expired.

Please ask your doctor, nurse, or pharmacist how to discard unused medicines safely.

Wash your hands before and after handling this medicine.

Clean the injection site with alcohol before applying the injector.

Do not touch, fan or blow on the area after cleaning with alcohol.

You or a family member can be trained to give this medicine at home.

Do not inject through clothing.

Do not inject into skin that is bruised, tender, red, hard or has scars or stretch marks.

Avoid injecting the medicine within 2 inches around the navel.

It may take several weeks for this medicine to fully work.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Do not use the medication any more than instructed.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Contact your doctor immediately if you experience any swelling of your hands, face, lips, eyes, throat or tongue.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• headaches
• pain, redness, swelling near injection

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• severe allergic reaction
• swelling of the face, mouth, tongue, or throat
• itching
• red, burning, or itchy skin
• shortness of breath

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.